The human pathogenic bacterium Clostridium perfringens secretes an enterotoxin (CpE) that targets claudins through its C-terminal receptor-binding domain (cCpE). Isoform-specific binding by CpE  causes dissociation of claudins and tight junctions (TJs), resulting in cytotoxicity and breakdown of the gut epithelial barrier. Here,  we present crystal structures of human claudin-9 (hCLDN-9) in complex with cCpE at 3.2 and 3.3

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Fonte:  www.pnas.org/cgi/doi/10.1073/pnas.1908929116