PK/TK (in vivo), ADME (in vitro) and BIOANALYSIS
Pharmacokinetics, toxicokinetics & drug metabolism studies generate information on absorption, distribution, metabolism and excretion important to the drug development. These studies help to define and optimize lead compounds; characterize compound profiles; to define the bioavailability of different formulations; define species-related discrepancies and potential drug interactions; provide valuable data on exposure levels of compounds and their metabolites after single and repeated compound administration, giving support to toxicology studies interpretation.
- Exploratory assessment of dose proportionality;
- Toxicokinetic studies;
- Development and validation of bioanalytical methods;
- Physicochemical properties determination (lipophilicity, solubility, pKa and chemical stability);
- DMPK/ADME in vitro assays (please consult);
Administration routes: Parenteral, enteral and topic (Single and multiple dosing available).
Matrices: Plasma, serum, whole blood, urine, feces, target organs and/or tissues from rodents.
Deliverables: Analysis of pharmacokinetics parameters with validated phoenix WinNolinTM software.